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Fogarty International Research Collaboration Award

Published on AidPage by IDILOGIC on Jun 24, 2005

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Examples of funded projects...

Neurocysticercosis is an infection of the brain caused by a tapeworm present in undercooked pork and is easily transmitted where sanitation is poor. It is a major cause of epilepsy in most developing countries and is an emerging disease within the U.S. The mechanism that causes inflammation in the brain is still not clearly understood. International teams of researchers from the U.S. and Peru are searching for mechanisms and innovative therapies, and have developed methods to monitor and determine the effectiveness of current treatments. Prostaglandins are hormones which function as key hormones in cancer and in human inflammatory diseases including asthma. Anti-inflammatory drugs such as aspirin and various steroids work in part by interfering with prostaglandin synthesis; however, they have various undesirable side-effects which have led to a search for alternatives. Important in this search is knowledge of how the body makes prostaglandins, a problem that has perplexed scientists for generations. To establish how they are made in humans, an international team of scientists is studying how they are made in sea corals, the richest known source of prostaglandins. The information they have obtained suggests avenues for development of new anti-inflammatory compounds which are more effective and have fewer side-effects. Each cell of the body contains a protein, P53, called the "tumor-suppressor-protein" which is responsible for orchestrating protective responses to stresses, such as exposure to radiation, lack of oxygen and other nutrients. If this protein cannot function correctly for any reason, different kinds of cancer can develop, due to uncontrolled cell division and other less well-known cellular reactions. An international team of scientists has determined additional effects of several of these defects on the cell's normal responses to stress, including an increase in chromosome defects such as breaks and duplications. This information is important for development of new cancer therapies and better selection of therapies for individual patients.

About this section

This section indicates the different types of projects which have been funded in the past. Only projects funded under Project Grants or Direct Payments for Specified Use should be listed here. The examples give potential applicants an idea of the types of projects that may be accepted for funding. The agency should list at least five examples of the most recently funded projects.